LncRNA BCYRN1-induced autophagy enhances asparaginase resistance in extranodal NK/T-cell lymphoma

Conclusions: It was found that BCYRN1 was a valuable prognostic biomarker in ENKTCL. BCYRN1 could promote resistance to ASP by inducing autophagy, which could be reversed by inhibition of autophagy. Our findings highlight the feasibility of combining autophagy inhibition and ASP in the treatment of ENKTCL.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Liang Wang, Jing Yang, He-nan Wang, Rui-ying Fu, Xin-di Liu, Ying-shi Piao, Li-qiang Wei, Jing-wen Wang, Luo Zhang Tags: Research Paper Source Type: research