The 14-3-3 σ protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1/2 signaling pathway

Conclusions: Our results indicate that 14-3-3σ plays a pivotal role in the anoikis resistance and metastasis of HCC cells, presumably by inhibiting EGFR degradation and regulating the activation of the EGFR-dependent ERK1/2 pathway. To our best knowledge, this is the first report of the role of 14-3-3σ in the anoikis resistance of HCC cells, offering new research directions for the treatment of metastatic cancer by targeting 14-3-3σ.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Jia Song, Yachong Liu, Furong Liu, Lu Zhang, Ganxun Li, Chaoyi Yuan, Chengpeng Yu, Xun Lu, Qiumeng Liu, Xiaoping Chen, Huifang Liang, Zeyang Ding, Bixiang Zhang Tags: Research Paper Source Type: research