Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist

Conclusion: The OECs that reached the lesion site were activated by the release of pro-inflammatory cytokines from activated microglia in the lesion site and secreted IL-1Ra to reduce neuroinflammation. Intravenous transplantation of OECs has high therapeutic effectiveness for the treatment of SCI via the secretion of IL-1Ra to reduce neuroinflammation.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Lijian Zhang, Xiaoqing Zhuang, P ä ivi Kotitalo, Thomas Keller, Anna Krzyczmonik, Merja Haaparanta-Solin, Olof Solin, Sarita Forsback, Tove J. Gr ö nroos, Chunlei Han, Francisco R. L ó pez-Pic ó n, Hechun Xia Tags: Research Paper Source Type: research