Three-dimensional Imaging Coupled with Topological Quantification Uncovers Retinal Vascular Plexuses Undergoing Obliteration

Conclusion: Coupling 3-D LSFM with topological quantification uncovered the retinal vasculature undergoing hyperoxia-induced obliteration from the secondary (outer) plexus to the vertical sprouts. The use of clustering coefficients, Euler's number, and PCA provided new network insights into OIR-associated vascular obliteration, with translational significance for investigating therapeutic interventions to prevent visual impairment.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Chih-Chiang Chang, Alison Chu, Scott Meyer, Yichen Ding, Michel M. Sun, Parinaz Abiri, Kyung In Baek, Varun Gudapati, Xili Ding, Pierre Guihard, Kristina I. Bostrom, Song Li, Lynn K. Gordon, Jie J. Zheng, Tzung K. Hsiai Tags: Research Paper Source Type: research