Apolipoprotein E, low-density lipoprotein receptor, and immune cells control blood-brain barrier penetration by AAV-PHP.eB in mice

Conclusions: Our findings demonstrate that the ApoE-LDLR pathway underlies the CNS tropism of AAV-PHP.eB and that the immune system contributes to the strain specificity of AAV-PHP.eB.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Bao-Shu Xie, Xin Wang, Yao-Hua Pan, Gan Jiang, Jun-Feng Feng, Yong Lin Tags: Research Paper Source Type: research