M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice

Conclusions: Our results showed, for the first time, that microglia regulate glial scar formation via small extracellular vesicles, indicating that M2 microglial small extracellular vesicles could represent a new therapeutic approach for stroke.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Zongwei Li, Yaying Song, Tingting He, Ruoxue Wen, Yongfang Li, Tingting Chen, Shuxian Huang, Yongting Wang, Yaohui Tang, FanXia Shen, Heng-Li Tian, Guo-Yuan Yang, Zhijun Zhang Tags: Research Paper Source Type: research