Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells

Conclusions: NHE1 plays a role in developing glioma immunosuppressive TME in part by dysregulating glucose metabolism of GAMs and emerges as a therapeutic target for improving glioma immunity.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Md Nabiul Hasan, Lanxin Luo, Dawei Ding, Shanshan Song, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Lesley M. Foley, Xiudong Guan, Gary Kohanbash, T. Kevin Hitchens, Maria G. Castro, Zhongling Zhang, Dandan Sun Tags: Research Paper Source Type: research