Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer

Conclusion: Our results suggest that AA contributes to an unfavorable clinical outcome of OC by impacting the phenotype of tumor-associated macrophages. Besides critical AA-regulated signal transduction proteins identified in the present study, PLA2G2A might represent a potential prognostic tool and therapeutic target to interfere with OC progression.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Raimund Dietze, Mohamad K. Hammoud, Mar í a G ó mez-Serrano, Annika Unger, Tim Bieringer, Florian Finkernagel, Anna M. Sokol, Andrea Nist, Thorsten Stiewe, Silke Reinartz, Viviane Ponath, Christian Preu ß er, Elke Pogge von Strandmann, Sabine M ü ller Tags: Research Paper Source Type: research