Tofacitinib restores the balance of γ δ Treg/ γ δ T17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome

Conclusions: Recovery of γδTreg/γδT17 cell balance was a novel mechanism by which TOF alleviated RA. Meanwhile, NLRP3 played a pivotal role in the process of TOF-mediated γδT17 cell activation.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Xinyu Yang, Ning Zhan, Yang Jin, Hanzhi Ling, Chipeng Xiao, Zhen Xie, Hao Zhong, Xinxin Yu, Runhua Tang, Jinglan Ma, Jubo Guan, Guoyu Yin, Gan Wu, Liangjing Lu, Jianguang Wang Tags: Research Paper Source Type: research