H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts

Conclusion: Our data demonstrated that upregulation of COL6A1 activated by H3K27 acetylation promoted the cell migration and invasion by suppressing STAT1 pathway in OS cells. Moreover, COL6A1 can be packaged into OS cell-derived exosomes and activate CAFs to promote OS metastasis.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Ying Zhang, Zhaoyong Liu, Xia Yang, Weiqing Lu, Yelong Chen, Youbin Lin, Jin Wang, Suxia Lin, Jing-Ping Yun Tags: Research Paper Source Type: research