Identification of the WNK-SPAK/OSR1 Signaling Pathway in Rodent and Human Lenses [Lens]

Conclusions.
Our results show that the WNK 1, 3, 4, OSR1, and SPAK signaling system known to play a role in regulating the phosphorylation status, and hence activity of the CCCs in other tissues, is also present in the rat and human lenses. The increased susceptibility of SPAK lenses to opacification suggests that disruption of this signaling pathway may compromise the ability of the lens to control its volume, and its ability to maintain its transparency.

Source: Investigative Ophthalmology - January 13, 2015 Category: Opthalmology Authors: Vorontsova, I., Lam, L., Delpire, E., Lim, J., Donaldson, P. Tags: Lens Source Type: research