Pulmonary Surfactant Protein A Is Expressed in Mouse Retina by Muller Cells and Impacts Neovascularization in Oxygen-Induced Retinopathy [Retinal Cell Biology]

Conclusions.
Retinal and Müller cell SP-A is up-regulated via the NFB pathway and up-regulated during the hypoxia phase of OIR. Absence of SP-A attenuates NV in the OIR model. Thus SP-A may be a marker of retinal inflammation during NV.

Source: Investigative Ophthalmology - January 9, 2015 Category: Opthalmology Authors: Bhatti, F., Ball, G., Hobbs, R., Linens, A., Munzar, S., Akram, R., Barber, A. J., Anderson, M., Elliott, M., Edwards, M. Tags: Retinal Cell Biology Source Type: research