Therapy-induced Deletion in 11q23 Leading to Fusion of KMT2A With ARHGEF12 and Development of B Lineage Acute Lymphoplastic Leukemia in a Child Treated for Acute Myeloid Leukemia Caused by t(9;11)(p21;q23)/KMT2A-MLLT3

Conclusion: The patient sequentially developed AML and ALL with three leukemia-specific genomic abnormalities in her bone marrow cells, two of which were KMT2A-rearrangements.

Source: Cancer Genomics and Proteomics - January 8, 2021 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., ANDERSEN, K., EILERT-OLSEN, M., ZELLER, B., MUNTHE-KAAS, M. C., BUECHNER, J., OSNES, L. T. N., MICCI, F., HEIM, S. Tags: Articles Source Type: research