Trial design of comparing patient-specific versus weight-based protocols to treat vaso-occlusive episodes in sickle cell disease (COMPARE-VOE)

Painful vaso-occlusive episodes (VOE) are the most common reason for emergency department (ED) visits experienced by patients with sickle cell disease (SCD). The National Heart, Lung and Blood Institute (NHLBI) evidence-based recommendations for VOE treatment are based primarily on expert opinion. In this randomized controlled trial (RCT), we will compare changes in pain scores between patients randomized to a patient-specific analgesic protocol versus those randomized to a weight-based analgesic protocol, as recommended by the NHLBI guidelines.

Source: Contemporary Clinical Trials - December 18, 2020 Category: Radiology Authors: Stephanie O. Ibemere, Sarah B. Dubbs, Huiman X. Barnhart, Jacqueline L. Brown, Caroline E. Freiermuth, Patricia Kavanagh, Judith A. Paice, John J. Strouse, R. Gentry Wilkerson, Paula Tanabe, on behalf of the COMPARE-VOE study investigators Source Type: research