Iron-mediated degradation of ribosomes under oxidative stress is attenuated by manganese [Cell Biology]

We report that Fe2+ promotes degradation of all rRNA species of the yeast ribosome and that it is bound directly to RNA molecules. Furthermore, we demonstrate that Mn2+ competes with Fe2+ for rRNA-binding sites and that protection of ribosomes from Fe2+-mediated rRNA hydrolysis correlates with the restoration of cell viability. Our data, therefore, suggest a relationship between these two transition metals in controlling ribosome stability under oxidative stress.

Source: Journal of Biological Chemistry - December 11, 2020 Category: Chemistry Authors: Daniel G. J. Smethurst, Nikolay Kovalev, Erica R. McKenzie, Dimitri G. Pestov, Natalia Shcherbik Tags: RNA Source Type: research