PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin [Protein Structure and Folding]

In conclusion, we reveal a functionally specific role of PFN2 as a stable interactor and regulator of the actin N-terminal acetyltransferase NAA80, and establish the modus operandi for NAA80-mediated actin N-terminal acetylation, a modification with a major impact on cytoskeletal dynamics.

Source: Journal of Biological Chemistry - December 4, 2020 Category: Chemistry Authors: Rasmus Ree, Laura Kind, Anna Kaziales, Sylvia Varland, Minglu Dai, Klaus Richter, Adrian Drazic, Thomas Arnesen Tags: Enzymology Source Type: research