Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis [Genomics and Proteomics]

This study adds novel important knowledge on amyloid LC processing: although our data do not exclude that proteolysis of native LC dimers may destabilize their structure and favor fibril formation, the data show that LC deposition largely precedes the proteolytic events documentable in mature AL fibrils.

http://www.jbc.org/content/295/49/16572.short?rss=1

Source: Journal of Biological Chemistry - December 4, 2020 Category: Chemistry Authors: Francesca Lavatelli, Giulia Mazzini, Stefano Ricagno, Federica Iavarone, Paola Rognoni, Paolo Milani, Mario Nuvolone, Paolo Swuec, Serena Caminito, Masayoshi Tasaki, Antonio Chaves-Sanjuan, Andrea Urbani, Giampaolo Merlini, Giovanni Palladini Tags: Protein Structure and Folding Source Type: research