Changing partners: transcription factors form different complexes on and off chromatin

The current knowledge on how protein–protein interactions regulate the function of transcription factors (TFs) has remained limited due to an incomplete knowledge of their interaction partners. In their recent work, Chen and colleagues (Li et al, 2015) analyse the interactome of 56 TFs and reveal distinct chromatin-associated and soluble TF complexes.

Source: Molecular Systems Biology - January 21, 2015 Category: Molecular Biology Authors: Ji, Z., Sharrocks, A. D. Tags: Network Biology, Post-translational Modifications, Proteolysis & Proteomics, Transcription News and Views Source Type: research