Latent TGF-beta binding protein-1 plays an important role in craniofacial development

Conclusions: Our experiments found that ltbp1 was expressed in zebrafish mandibular jaw cartilages and the surrounding muscles. The ltbp1 knockdown zebrafish exhibited phenotypes consistent with Ltbp1 knockout mice. And loss of ltbp1 function lead to significant mandibular jaw defects and affect both jaw cartilages and surrounding muscles.
Source: Journal of Applied Oral Science - Category: Dentistry Source Type: research