Branched-chain ketoacid overload inhibits insulin action in the muscle [Metabolism]

This study provides evidence for FA-mediated regulation of BCAA-catabolizing enzymes and BCKA content and highlights the biological role of BCKAs in regulating muscle insulin signaling and function.

Source: Journal of Biological Chemistry - November 13, 2020 Category: Chemistry Authors: Dipsikha Biswas, Khoi T. Dao, Angella Mercer, Andrew M. Cowie, Luke Duffley, Yassine El Hiani, Petra C. Kienesberger, Thomas Pulinilkunnil Tags: Signal Transduction Source Type: research