Withdrawal: Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of {beta}1-integrin, ERK, and NF-{kappa}B. [Withdrawals/Retractions]

This article has been withdrawn by Praveen Bhoopathi, Chandramu Chetty, Sateesh Kunigal, and Sajani S. Lakka upon request by the Journal. Sravan K. Vanamala and Jasti S. Rao could not be reached. The Journal states that in Fig. 2A, the ERK immunoblot contains a splice and the pERK immunoblot was inappropriately manipulated. Fig. 2C was inappropriately manipulated. Lanes 1–4 of the GAPDH immunoblot from Fig. 3A were reused in lanes 1–4 of the GAPDH immunoblot in Fig. 3C. Lane 5 of the GAPDH immunoblot from Fig. 3A was reused in lane 7 of the same immunoblot and in lane 5 of the GAPDH immunoblot from Fig. 3C. Lane 6 of the GAPDH immunoblot from Fig. 3A was reused in lane 8 of the same immunoblot and in lanes 6 and 7 of the GAPDH immunoblot from Fig. 3C. Lanes 5 and 7 of the pERK immunoblot from Fig. 3C are the same. Fig. 4A was inappropriately manipulated. In Fig. 4C, the first two lanes of the pERK immunoblot are the same. Both immunoblots in this figure were inappropriately manipulated. In Fig. 4D, the upper and lower bands in lane 3 of the cleaved caspase 3 immunoblot are the same. Also in Fig. 4D, the pERK bands in lanes 1 and 2 are the same. In Fig. 5A, lanes 3 and 7 of the pERK immunoblot are the same. Both immunoblots in this figure panel were inappropriately manipulated. The withdrawing authors were not able to locate the...

Source: Journal of Biological Chemistry - November 6, 2020 Category: Chemistry Authors: Praveen Bhoopathi, Chandramu Chetty, Sateesh Kunigal, Sravan K. Vanamala, Jasti S. Rao, Sajani S. Lakka Tags: Withdrawals/Retractions Source Type: research