A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer

A new dinuclear complex of formula [{Re(CO)3(py)}2( µ-4,4 ” -azobpy)](PF6)2, with py = pyridine and 4,4 ” -azobpy = 4,4 ” -azobis(2,2 ’ -bipyridine), has been synthesized and characterized by spectroscopic and electrochemical techniques. The symmetrical nature of the dimetallic cation has been confirmed by nuclear magnetic resonance (NMR) measurements. When adding L-cysteine or L-glutathione, large and rapid changes in its UV-Vis absorption spectra were observed, which can be used for detecting both biologically relevant thiols. A promising activity for using this complex as a chemotherapeutic agent for bone cancer was also disclosed. Quantum mechanical calculations supported the experimental data.
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research