Stem-like Cells from Invasive Breast Carcinoma Cell Line MDA-MB-231 Express a Distinct Set of Eph Receptors and Ephrin Ligands

Conclusion: The up-regulation of transcripts for EPHA8 and its cognate ligand, ephrin-A5, in the stem cells isolated from MDA-MB-231, suggest their involvement in the invasiveness of this cell line. Based on literature reports, we propose the role of EPHA8 and ephrin-A5 in MDA-MB-231 stem cells via the PI3K-AKT-mTOR pathway.

Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: LUCERO, M., THIND, J., SANDOVAL, J., SENAATI, S., JIMENEZ, B., KANDPAL, R. P. Tags: Experimental Studies Source Type: research