Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis

Conclusion: Thus, our study suggested the functional interaction of G9a, Dclk1 and Mapk pathway in the Kras-driven pancreatic carcinogenesis. The inhibition of G9a may suppress the initiation of oncogenic Kras-driven pancreatic carcinogenesis.

Source: Cancer Genomics and Proteomics - October 24, 2020 Category: Cancer & Oncology Authors: KATO, H., TATEISHI, K., FUJIWARA, H., IJICHI, H., YAMAMOTO, K., NAKATSUKA, T., KAKIUCHI, M., SANO, M., KUDO, Y., HAYAKAWA, Y., NAKAGAWA, H., TANAKA, Y., OTSUKA, M., HIRATA, Y., TACHIBANA, M., SHINKAI, Y., KOIKE, K. Tags: Experimental Studies Source Type: research