Does vancomycin administered at an empirical dose ensure coverage of pediatric patients against gram-positive pathogens?

Conclusion: A minimum empirical dose of 60mg/kg per day should be prescribed for pediatric patients in intensive care units with preserved renal function. The use of the ratio between the area under the curve and minimum inhibitory concentration in the evaluation of vancomycin coverage is recommended to achieve the desired outcome, since the pharmacokinetics are altered in these patients, which may impact the effectiveness of the antimicrobial.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research