155P Interleukin 17F and vasculogenic mimicry: Potential therapeutic targets in oral tongue cancer?

ConclusionOur findings confirm the role of VM in OTSCC carcinogenesis. Here, we suggest that IL-17F counteracts the tumorigenic activity in OTSCC, in part, through the antiangiogenic effect in the tumour microenvironment, and hence further studies are warranted. Harnessing IL-17F in the current management approaches in advanced OTSCC patients may lead to promising immunotherapeutic strategies against OTSCC.Legal entity responsible for the studyUniversity of Helsinki.FundingUniversity of Helsinki, Doctoral program in clinical research (KLTO).DisclosureThe author has declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research