The effect of IL‐17 on the production of proinflammatory cytokines and matrix metalloproteinase‐1 by human periodontal ligament fibroblasts

ConclusionsIL‐17 upregulated the production of IL‐6 and MMP‐1 sequentially in HPDLF. IL‐6/sIL‐6R may enhance the effects of IL‐1β on MMP‐1 production. The present results suggest that IL‐17 induces MMP‐1 production not only directly, but also indirectly by promoting IL‐6 production, thus resulting in the degradation of collagens in the PDL.

Source: Orthodontics and Craniofacial Research - January 13, 2014 Category: Dentistry Authors: M. Shibata, Y. Shintaku, K. Matsuzaki, S. Uematsu Tags: Original Article Source Type: research