The changes in melanocyte number and melanin density occurring in vitiligo patches during 180 days of narrow band-ultraviolet B therapy

This study aimed to follow up the changes in melanocyte number and melanin density in vitiliginous patches during NB-UVB therapy for vitiligo patients. Patients and methodsThis study included 25 patients with nonsegmental vitiligo. NB-UVB therapy was given twice weekly for 6 months. Four skin biopsies were obtained from each patient at days 0, 30, 90, and 180. Biopsies were stained using hematoxylin and eosin stain, Masson–Fontana stain, and human melanoma black-45 (HMB-45) antibody. Qualitative and quantitative measurements were determined for both melanocyte number and melanin density. ResultsThere was a significant increase in the number of HMB-45-negative melanocytes (P
Source: Journal of the Egyptian Women’s Dermatologic Society - Category: Dermatology Tags: Original articles Source Type: research