Loss of Periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity

Conclusion:
Together our data suggest that loss of Postn in an ErbB2/Neu/HER2 overexpression model results in apocrine-like tumors that activate an AR-dependent pathway. This may have important implications for the treatment of breast cancers involving the therapeutic targeting of periostin or Notch signaling.

Source: Breast Cancer Research - January 16, 2015 Category: Cancer & Oncology Authors: Roshan SriramVivian LoBenjamin PryceLilia AntonovaAlan MearsManijeh DaneshmandBruce McKaySimon ConwayWilliam MullerLuc Sabourin Source Type: research