Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase

Conclusion: These findings demonstrate that: 1) The "Warburg effect" is dispensable, 2) loss of the LDHAB gene is not only inconsequential to viability but fosters greater mitochondrial energy, and 3) drugs that target LDHA/B are likely to be ineffective without a plausible combination second drug target.

Source: Cancer Genomics and Proteomics - August 27, 2020 Category: Cancer & Oncology Authors: MAZZIO, E., BADISA, R., MACK, N., CASSIM, S., ZDRALEVIC, M., POUYSSEGUR, J., SOLIMAN, K. F. A. Tags: Experimental Studies Source Type: research