Histone deacetylase inhibitor sodium butyrate suppresses DNA double strand break repair induced by etoposide more effectively in MCF-7 cells than in HEK293 cells

Conclusions:
These studies suggest that sodium butyrate treatment leads to a different degree of chromatin relaxation in HEK293 and cancerous MCF-7 cells, which results in differential sensitivity to the toxic effects of etoposide in controlling damaged DNA repair.

Source: BMC Biochemistry - January 16, 2015 Category: Biochemistry Authors: Liping LiYouxiang SunJiangqin LiuXiaodan WuLijun ChenLi MaPengfei Wu Source Type: research