Malignant melanoma: Underlying epigenetic mechanisms
Hussein Sabit, Feroze Kaliyadan, Ritesh G MenezesIndian Journal of Dermatology, Venereology, and Leprology 2020 86(5):475-481
Although malignant melanoma is not the most common type of skin cancer, it is the most aggressive and fatal type as it can spread out and metastasize progressively. Early diagnosis and interventions lead to improved patient survival. The incidence rate of melanoma is dramatically increasing, with a few newer therapeutic options available. Therefore, establishing a reliable genetic or epigenetic-based diagnostic and prognostic tool is really important. In this review, we highlight the underlying epigenetic mechanisms involved in melanoma. Furthermore, the epigenetic-based therapeutic options will be also discussed. One of the key areas of discussion will be microRNA which is a small, single-stranded RNA molecule that serves as a regulatory element and found to regulate nearly a third of human genes. MicroRNAs play a role in a wide range of diseases including cancer. In malignant cells, it regulates cell proliferation, invasion, and metastasis.
Source: Indian Journal of Dermatology, Venereology and Leprology - Category: Dermatology Authors: Hussein Sabit Feroze Kaliyadan Ritesh G Menezes Source Type: research
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