Transfer of antibiotic-resistance genes via phage-related mobile elements

Publication date: Available online 15 January 2015 Source:Plasmid Author(s): Maryury Brown-Jaque , William Calero-Cáceres , Maite Muniesa Antibiotic resistance is a major concern for society because it threatens the effective prevention of infectious diseases. While some bacterial strains display intrinsic resistance, others achieve antibiotic resistance by mutation, by the recombination of foreign DNA into the chromosome or by horizontal gene acquisition. In many cases, these three mechanisms operate together. Several mobile genetic elements (MGEs) have been reported to mobilize different types of resistance genes and despite sharing common features, they are often considered and studied separately. Bacteriophages and phage-related particles have recently been highlighted as MGEs that transfer antibiotic resistance. This review focuses on phages, phage-related elements and on composite MGEs (phages-MGEs), involved in antibiotic resistance mobility. We review common features of these elements, rather than differences and provide a broad overview of the antibiotic resistance transfer mechanisms observed in nature, which is a necessary first step to controlling them.
Source: Plasmid - Category: Biotechnology Source Type: research