Recognition of lysyl oxidase as a potential predictive biomarker for oral squamous cell carcinoma: an immunohistochemical study.

CONCLUSIONS: LOX has a 'pro-neoplastic' effect as it modulates the host stroma to favour increasing tumour mass and worsening prognosis. Increased expression of LOX causes increased collagen fibre cross-linkage that 'stiffens' the stromal matrix. This increases compressive stresses contributing to tissue hypoxia that elevates Rho GTPase-dependent cytoskeletal tension leading to erratic tumour cell morphogenesis that in turn confers motility to these cells resulting in metastasis. Inhibitors of LOX can potentially down-regulate LOX levels in the tumour micro-environment by controlling tissue hypoxia and curtailing the production of hypoxic LOX molecules. PMID: 32744444 [PubMed - as supplied by publisher]
Source: Minerva Stomatologica - Category: Dentistry Tags: Minerva Stomatol Source Type: research