TPR Podcast Episode #7: Interview with Guy Weinberg about lipid rescue therapy

NOTE: The audio quality of this recording is understandable but definitely choppy and sub-optimal. However, the concepts discussed are so important that we are uploading the file for those who want to listen. We will also post a transcript of the discussion in the next few days. In this episode the TPR team interviews Dr. Guy Weinberg from the Department of Anesthesia at the University of Illinois Medical Center in Chicago. Dr. Weinberg, among his many other accomplishments, was instrumental in developing the modality of lipid rescue therapy in treating cardiotoxicity caused by parenteral injection of local anesthetics such as bupivacaine. He also runs the website LipidRescue™ Resuscitation. The discussion is worth listening to (or reading) in its entirety. The following are summaries of some of Dr. Weinberg’s key take-home points: Although the recipe for administering 20% Intralipid in cases of parenteral local anesthetic has been well worked out, the optimal dose for treating oral ingestion of lipophilic cardiotoxic or neurotoxic agents has not. With parenteral local anesthetic injection serum levels peak quickly and fall rapidly. With oral ingestions — especially of sustained-release products — levels are more sustained and may even increase for a period of time. These 2 different scenarios may very well have to be treated differently. The clinician should avoid administering too much lipid emulsion, as this can cause adverse effects from fat overload. As a ...
Source: The Poison Review - Category: Toxicology Authors: Tags: Podcast Source Type: news