Targeting interferon response genes sensitizes aromatase inhibitor resistant breast cancer cells to estrogen-induced cell death

Conclusion: Overall, these results demonstrate that constitutive overexpression of ISGs enhances the progression of AI-resistant breast cancer and that suppression of IFITM1 and other ISGs sensitizes AI-resistant cells to estrogen-induced cell death.

http://breast-cancer-research.com/content/17/1/6

Source: Breast Cancer Research - January 15, 2015 Category: Cancer & Oncology Authors: Hye ChoiAsona LuiJoshua OgonyRifat JanPeter SimsJoan Lewis-Wambi Source Type: research