Quinones as preventive agents in Alzheimer ’s diseases: focus on NLRP3 inflammasomes

AbstractObjectivesAlzheimer ’s disease (AD) is a hidden neurological degenerative disease, which main clinical manifestations are cognitive dysfunction, memory impairment and mental disorders. Neuroinflammation is considered as a basic response of the central nervous system. NLRP3 (Nucleotide‐binding domain leucine‐rich repeat (NLR) and pyrin domain containing receptor 3) inflammasome is closely related to the occurrence of neuroinflammation. Activation of the NLRP3 inflammasome results in the release of cytokines, pore formation and ultimately pyroptosis, which has demonstrated one of the critical roles in AD path ogenesis. Inhibition of the activity of NLRP3 is one of the focuses of the research. Therefore, NLRP3 represents an attractive pharmacological target, and discovery compounds with good NLRP3 inhibitory activity are particularly important.Key findingsQuinones have good neuroprotective effects and prevent AD, which may be related to their regulation of inflammatory response. The molecular docking was used to explore 12 quinones with AD prevention and treatment and NLRP3. Docking results showed that the combination of anthraquinones and NLRP3 were the best, and the top two chemical compounds were Purpurin and Rhein, which are the most promising NLRP3 inhibitors.SummaryThese quinones may provide the theoretical basis for finding lead compounds for novel neuroprotective agents.

Source: Journal of Pharmacy and Pharmacology - July 14, 2020 Category: Drugs & Pharmacology Authors: Da ‐bao Chen, Hua‐wu Gao, Cheng Peng, Shao‐qiang Pei, An‐ran Dai, Xue‐ting Yu, Peng Zhou, Yan Wang, Biao Cai Tags: Review Source Type: research