Concurrent administration with multivalent metal cation preparations or polycationic polymer preparations inhibits the absorption of raltegravir via its chelation

ConclusionsThe interaction of RAL with Al(OH)3, LaCO3, Bxl, or Svl can inhibit RAL absorption into the gastrointestinal tract, and thus, the multivalent metal cation and polycationic polymer are the modifying factors that can affect RAL pharmacokinetics.

Source: Journal of Pharmacy and Pharmacology - July 12, 2020 Category: Drugs & Pharmacology Authors: Yuki Enoki, Norihiro Suzuki, Motoyasu Ito, Eri Uchiyama, Nagomi Kishi, Chihiro Ito, Yuki Kitahiro, Kazuki Sakamoto, Kazuaki Taguchi, Yuta Yokoyama, Junko Kizu, Kazuaki Matsumoto Tags: Research Paper Source Type: research