Tissue-type plasminogen activator and plasminogen activator inhibitor type 1 in patients with symptomatic lower extremity artery disease.

CONCLUSIONS: High t-PA Ag concentrations in LEAD patients suggest damage to the endothelium which comprises the main source of this factor. With high PAI-1 Ag levels, inactive fibrinolytic t-PA-PAI-1 complexes are formed. Increasing fibrinogen concentrations at the subsequent stages in accordance with the Fontaine classification, indicate increasing inflammation. Moreover, heightened values of D-dimer reflect an increased secondary fibrinolysis activation as patients get older and impaired extremity vascularization, manifested by the decreasing ABI, progresses. PMID: 32643893 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32643893?dopt=Abstract

Source: Minerva Cardioangiologica - July 10, 2020 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research