Dual effects of S ‐adenosyl‐methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP+
Conclusions(1) SAM might induce neurotoxic or neuroprotective effects on PC12 cells, depending on the exposure conditions; (2) DNMT inhibitors might attenuate the MPP+ exacerbation toxicity induced by SAM; (3) DNA methylation might be involved in the observed effects of SAM (needs further investigation).
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Rebeca Araujo Cantelmo,
Neife Aparecida G. Santos,
Antonio Cardozo Santos,
S âmia Regiane Lourenço Joca Tags: Research Paper Source Type: research