Genetic Polymorphisms of CYP2D6: Prevalence in Healthy Kurds

Conclusion: The data add to our knowledge of CYP2D6 alleles, the genotypes and the distributions of predicted phenotypes in Kurds. Majority of the observed variant alleles confer no function and gene duplication. CYP2D6 polymorphisms were found to be very heterogeneous in relation to genotype frequencies. Further study in relation to the evaluation of drug therapy adjustment based on CYP2D6 genotype may help to understand the clinical consequences of CYP2D6 polymorphisms.

Source: Current Pharmacogenomics and Personalized Medicine - June 30, 2020 Category: Genetics & Stem Cells Source Type: research