Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis

Conclusion:
This study suggests that CTCs and BM-DTCs detected in BC PDX-bearing mice may represent a valuable and unique preclinical model for investigating the role of these rare cells in tumor metastases.

Source: Breast Cancer Research - January 9, 2015 Category: Cancer & Oncology Authors: Mario GiulianoSabrina HerreraPavel ChristinyChad ShawChad CreightonTamika MitchellRaksha BhatXiaomei ZhangSufeng MaoLacey DobroleckiAhmed Al-rawiFengju ChenBianca VenezianiXiang ZhangSusan HilsenbeckAlejandro ContrerasCarolina GutierrezRinath JeselsohnMot Source Type: research