A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation

Conclusion:
Diverse transmembrane signals are required for mammary epithelial cell growth in 2D and 3D conditions. Strikingly, we define novel roles for axonal pathfinding receptors and ligands and the endothelin receptor in both growth and differentiation.

Source: Breast Cancer Research - January 9, 2015 Category: Cancer & Oncology Authors: Angela BurleighSteven McKinneyJazmine BrimhallDamian YapPeter EirewSteven PoonViola NgAdrian WanLeah PrenticeLois AnnabJ BarrettCarlos CaldasConnie EavesSamuel Aparicio Source Type: research