Gut microbiome ‐mediated modulation of hepatic cytochrome P450 and P‐glycoprotein: impact of butyrate and fructo‐oligosaccharide‐inulin

ConclusionThe expression of hepatic genes implicated in drug metabolism and transport displays sensitivity to the microbiome, microbiome ‐derived metabolites and a microbial‐targeted intervention. Our study may provide the impetus to explore microbiota‐targeted interventions in normalising host metabolic activity and reducing inter‐individual variability in drug pharmacokinetics.

Source: Journal of Pharmacy and Pharmacology - April 25, 2020 Category: Drugs & Pharmacology Authors: Jacinta Walsh, Cassandra E. Gheorghe, Joshua M. Lyte, Marcel Wouw, Marcus Boehme, Timothy G. Dinan, John F. Cryan, Brendan T. Griffin, Gerard Clarke, Niall P. Hyland Tags: Research Paper Source Type: research