Pharmacokinetics and in vivo distribution of optimized PLGA nanoparticles for pulmonary delivery of levofloxacin

ConclusionThe optimized formulation with desirability value 0.9612 showed mean particle size of 146 nm, MMAD of 4.40 μm and sustained the drug release up to 120 h in simulated lung fluid. Augmentation inCmax (1.71 ‐fold), AUC 0‐∞ (5.46‐fold), Mean Residence Time (6.64‐fold) and AUC/MIC (6.21‐fold) of LN through pulmonary route was found to significantly higher (P< 0.05) than levofloxacin (p. o.).

Source: Journal of Pharmacy and Pharmacology - April 25, 2020 Category: Drugs & Pharmacology Authors: Sunny R. Shah, Hani R. Prajapati, Devang B. Sheth, Ekta M. Gondaliya, Amit J. Vyas, Moinuddin M. Soniwala, Jayant R. Chavda Tags: Research Paper Source Type: research