Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR ‐143‐3p/TGF‐β1 axis

ConclusionsOur studies demonstrated that the protective effect of MET on DN was attributed to the inhibition of proliferation, inflammation and ECM accumulation in mesangial cells via H19/miR ‐143‐3p/TGF‐β1 axis, which suggested that the H19/miR‐143‐3p/TGF‐β1 axis could be a valuable target for DN therapies.

Source: Journal of Pharmacy and Pharmacology - May 10, 2020 Category: Drugs & Pharmacology Authors: Jiang Xu, Ping Xiang, Linqing Liu, Jianran Sun, Shandong Ye Tags: Research Paper Source Type: research