Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism

ConclusionsTripterygium wilfordii chronotoxicity was associated with diurnal variations in triptolide pharmacokinetics and circadian expression of hepatic Cyp3a11 regulated by circadian clock. Our findings may have implications for improving TW treatment outcome with a chronotherapeutic approach.

Source: Journal of Pharmacy and Pharmacology - May 31, 2020 Category: Drugs & Pharmacology Authors: Huan Zhao, Yongbin Tong, Danyi Lu, Baojian Wu Tags: Research Paper Source Type: research