Imbalanced response of ATP-binding cassette transporter A1 and CD36 expression to increased oxidized low-density lipoprotein loading contributes to the development of THP-1 derived foam cells

In conclusion, the more preferentially suppressed ABCA1 expression as compared with CD36 at higher doses of oxLDL stimulation may be the initiator for the formation of macrophage-derived foam cells.

Source: Journal of Biochemistry - January 6, 2014 Category: Biochemistry Authors: Liu, H.-Y., Cui, H.-B., Chen, X.-M., Chen, X.-Y., Wang, S.-H., Du, W.-P., Zhou, H.-L., Zhao, R.-C., Zhou, Y., Liu, Y.-H., Cui, C.-C., Huang, C. Tags: Regular Papers Source Type: research