Does Metoprolol Influence the Risk of Exacerbation in a High-risk COPD Patient Population?

Synopsis: This prospective randomized trial investigates the influence of metoprolol in comparison with placebo on the risk of chronic obstructive pulmonary disease exacerbations. Contrary to results in previous observational studies, the results showed that patients with moderate to severe chronic obstructive pulmonary disease, with no prior indication for beta blockers, were at similar risk for exacerbations as the placebo group. The metoprolol group was associated with a higher risk of exacerbation leading to mechanical ventilation. In addition, metoprolol was associated with worsening symptoms of breathlessness.
Source: Clinical Pulmonary Medicine - Category: Respiratory Medicine Tags: Pulmonary Trends Source Type: research