An NCBP3-Domain Protein Mediates Meiotic Silencing by Unpaired DNA

We report here that SAD-8, a protein similar to human NCBP3, also mediates silencing. Although SAD-8 is not essential for either vegetative or sexual development, it is required for MSUD. SAD-8 localizes predominantly in the nucleus and interacts with both NCBP1 and NCBP2. Similar to NCBP1 and NCBP2, SAD-8 interacts with a component (Argonaute) of the perinuclear meiotic silencing complex (MSC), further implicating the involvement of cap-binding proteins in silencing.

Source: G3: Genes Genomes Genetics - May 31, 2020 Category: Genetics & Stem Cells Authors: Boone, E. C., Xiao, H., Vierling, M. M., Decker, L. M., Sy, V. T., Kennedy, R. F., Bonham, M. A., Schmitz, S. F., John, A. M., Hammond, T. M., Shiu, P. K. T. Tags: Investigations Source Type: research